Gladstone Institutes

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located at U.C. San Francisco

 

Linking HIV and Stem Cells:  Scientists marvel at timing of understanding both stem cell and HIV biology at the same time.

Video:  Fascinating nexus linking stem cells and HIV: “The biology of stem cells and the biology of HIV came slamming together at the same time.” A CIRM speaker, Warner Greene, PhD. On video, first 2 minutes.   https://www.cirm.ca.gov/our-progress/video/hiv-and-stem-cells-warner-greene-cirm-science-writers-seminar

HIV Particles Do Not Cause AIDS, Our Own Immune Cells Do

The virus turns host immune cells into suicide machines, using them to spread the virus and cause the progression from HIV to AIDS

Gladstone Press Release / August 27, 2015
SAN FRANCISCO, CA—Researchers from the Gladstone Institutes have revealed that HIV does not cause AIDS by the virus’s direct effect on the host’s immune cells, but rather through the cells’ lethal influence on one another.
“This study fundamentally changes our mindset about how HIV causes massive cell death, and puts the spotlight squarely on the infected cells in lymphoid tissues rather than the free virus,” says senior author Warner C. Greene, MD, PhD, director of the Gladstone Institute of Virology and Immunology. “By preventing cell-to-cell transmission, we may able to block the death pathway and stop the progression from HIV infection to AIDS.”